Tsunade wins mid difficulty.
-The impact Madara's Magatama made rivaled or surpassed what Base B, someone physically stronger than Ay, did with his lariat, but that power is focused into piercing form. Tsunade can take that power but far more concentrated with zero damage. So we can forget about any low level bombs doing serious enough damage to tear off entire limbs unless she lets it hit her unguarded or doesn't try to evade. Then there's her being able to survive Mabui's teleportation with minor cuts for whatever that is worth, but that doesn't really matter.
-Fish bomb feat is irrelevant because explosions like that are
much stronger underwater and this isn't an underwater fight. When it comes to C1 that is the only extraordinary explosion he's shown along side the squid that flipped over Turtle Island IIRC. Tsunade is fast enough to make sure she's not at the absolute center of any of these explosions.
-C2 is almost useless as Deidara would blow himself up. His only way to escape is to dive underground, but if he stops to do that Tsunade will pulverize him as her AoE is too large for him to evade while trying to burrow underground, and if she jumps then her AoE will roughly be the same strength as Sakura's. If push comes to shove Katsuyu can be summoned to protect her from C2.
-C4 is useless as he'd have to make distance between them to not get caught in the blast himself.
Match ends with her punching his guts out or with him getting caught in something of
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scale.