Besides the fact Tobirama's hiraishin is not as adaptable as Minato's because of the use of kunais, Tobirama's seems slower as well. He takes
You must be registered for see links
after teleporting to touch the target in the contrary
You must be registered for see links
. Maybe it's for that reason he wasn't that famed with it(not sure).
But Tobirama still has sensing abilities which is a great advantage while facing Sharingan users since they are capable
You must be registered for see links
from their eye in order to prevent from attack. Judging by
You must be registered for see links
scale of
You must be registered for see links
plus the fact Yata mirror can only protect from one side, i'm not totally sure Itachi's final Susanoo would protect effectively against that and even if it did, pretty sure it would be totally annihilated in the end, and Tobirama has 2edos here. While it's true Totsuka can seal edos, it actually has to hit the edos in question through the torso in order to connect with the soul. If he manages to, good for him, but it's not as if it would be as easy as some people make it seem. They are not blind immobile target like Nagato was.
Furthermore, like Rivaille explained, during this chapter, Tobirama managed to teleport Obito during this chapter
You must be registered for see links
, which once again prove that Hiraishin can swap places(Susanoo/Susanoo) user without the other since the Susanoo user
You must be registered for see links
to his chakra based attack. With the use of clone, Tobirama has the means to bypass the defense. Although like i've said earlier, Tobirama's Hiraishin seems a tad slower and not really adaptable, so this method would be difficult to work. What could give him an advantage though is the fact that Itachi has no knowledge on him when he spent his entire life fighting Uchihas day and night and thus knowing majority of their jutsus(Amaterasu, Susanoo and so on)