At least Itachi protected Sasuke as long as he was alive and even gave his life instead of killing him.
Madara wasn't able to protect no one. He couldn't even come to a compromise given the fact that Hashirama/Tobirama repeatedly won their battles.
Itachi was smarter and protected his brother from dying as long as he was alive, even tough he manipulated sasuke and hurt him, he would never kill him. while Madara chose to fight everyone and to be honest, he was the leader of his clan. Hashirama gave him multiple chances, but he never accepted them.
Izuna died because of madara's selfish desire to kill Senju.
Madara could've prevented Izuna's death by making peace with Senju, but he chose to fight, and he payed the price.
Whereas Itachi prevented the war and his brother's death, which was inevitable because he was an Uchiha and would get killed.
gg
Itachi all the way no doubt