First of all. Putting him down is going to be tough considering he has Karin's auto healing ability, and Orochimaru's Oral Rebirth and White Snake Power. Second of all, he still has access to the Sound 5's techniques. Sound Genjutsu to catch Kisame off guard for a finishing technique.
@The Bold, for those using conventional means, yes. Kisame's more than capable of killing through attrition or reducing him to a weak enough state that he can't fight back, like with Killer Bee. Sound Genjutsu won't last more then a few moments at best, with the absolute worst coming from Kisame snapping out of it with induced pain. Biting heavily into his lip or tongue similar to what he did against the mind probing breaks him out of it, Samehada heals him from the damage. Genjutsu's a very small factor in the overall battle and will be at best momentary distractions. If any Mizu Bunshin are up, they easily snap Kisame from the genjutsu. Kidomaru's webs aren't doing much, seeing as the chakra inside will either be absorbed quickly or Kisame ducks further down in a suiton pool he made, avoiding them. Kimimaro's bones are only really useful in the sense that digital shrapnel might catch Kisame off guard, but the guy was dodging Bee's attacks. Kimimaro's aren't ground breaking in terms of speed. Jirobo has nothing to offer, and Tayuya's genjutsu won't have a long lasting effect on him.
The fact that Kisame needs to fight CQC to actually kill Kabuto doesn't help much either, and even then he has Oral Rebirth if he takes a wound that'd normally be impossible to heal. Then there's the fact he can use Sakon's jutsu to make a copy of Orochimaru's True Form, and once it's blood is exposed, Kisame is paralyzed and dies a terrible death.
But he doesn't need to openly shred his skin in some cases, and others he doesn't need to directly fight him at all. A thousand feeding sharks present a large force that'll be able to either momentarily bind Kabuto if he's stuck in the water dome, or bite into his body. Not to mention that the
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, if he's in the dome or under the water (Where Kisame is likely to be,) then Kabuto's poison isn't effected him. Oral rebirth's a chakra sapping technique, might seem petty considering Kabuto's reserves, but when each solid contact with your foe or if you come too close to his weapon, pending on form. Yeah, it all adds up.
Water Dome isn't really of any help since Kabuto has a snake form he can turn into, and snakes can travel underwater. Combine that with his ability to split into numerous snakes and even turn into fluid, and you have him making an extremely easy escape.
He's almost, if not, Oro+, and I think Oro has a chance to defeat Kisame without Daikodan. He'd have issues taking out Manda AND Kabuto without Daikodan.
Though I might change my mind depending on what is presented.
The snakes can, but who's to say at which speed the snakes move underwater? Faster then a fused Kisame? Quicker then biological or suiton formed Sharks? Very difficult when they haven't been properly introduced to that environment to display that ability. Take away the fact that the Dome is massive, there's no where to hide. Kisame easily snacks and catches on them one after the other. Literally a few seconds of contact with one or decisive damage given on top of that will end 'em. Suiton sharks, a thousand or so, can be used to block off the exists of the dome or even a smaller set to perform the purpose of the technique.
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.
Kabuto's technique is not the same as the Hozuki ability, Kabuto relies on turning his body into a liquid based on the
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. It's not nearly as instant, the likely hood of it being able to fuse with bodys of water even lower, and it'll leave the snakes in a similar disposition in the dome or any size of suiton to that of the jelly fish, being carried around by whatever current, tide, or force can throw it around. If Manda confronts Kisame in the Dome or when he's fused, the snake doesn't stand a chance. Physical contact with Kisame in those instances is the worst thing someone can do, even if he has a formidable reserve, he's not leaving with most of his chakra, with Kisame being a more agile opponent and harder to lock onto then someone of his own size.
Edit: Well shit. Came late to the party. .
