I doubt sasuke will give up on his revenge i just think he will go about it a different way, or maybe just scream why at itachi lol sounds like something sasuke would do...If this is Itachi (check my theories XD), then this won't succeed since the Manga say the second tragedy of Sasuke's revenge has just begun..
That would lead to the conclusion that Itachi won't be able to do much.
And yes itachi is dead, madara took his body, i cant remember which chapter but yes hes dead