It's fairly ludicrous to say that Tobirama is the source of many issues presented in the manga.
The man established the infrastructure for the village and gave the Uchiha a prominent role to promote peace.
The only thing people seem to cling to when expressing their disapproval of him is the "issue" of the Police HQ.
If that's what flamed Madara's hatred, than Tobirama's gaging of the Uchiha as highly impressionable was correct.
He did not ostracize them, nor did he kill any of them after establishing the village.
He gave the clan an important role in the village and thought they'd do well fulfilling it.
Tobirama had the village's interests at heart when he demanded that the position of Hokage follow a democratic process.
If Madara was made Hokage without an election, he'd probably end up nominating fellow Uchiha for future spots.
That assumption is made off the fact that Madara has only ever been concerned with making sure his clan stays strong.