No, Sakura healed him some, Naruto cloaks.He can maintain a single Sharingan for several days of all out war, and this is in addition to using taxing jutsu and Mangekyo shots. Two Sharingan is by no means out of his stamina department in light of his latest feats. The increasing availability of Hashirama cells helps too.
What would worry me is in non-battle scenarios. He'd have to walk around blind-folded.