Hinata, chouji, sakura, kiba, lee, neji will have to get close range to Tsunade to attack her. The only ones I can see managing to back off without receiving a punch in their face here are Neji and probably lee...... The other 4 will be incapacitated here......
Tsunade still got her Genesis of Rebirth and Byakugou....... that means weapon from tenten, piercing shadows of shikamaru, won't work
Ino? Her jutsu is kinda slow, but she might be able to pull it off
Don't know about sai
After 2 or 3 rounds of attacks the fight will become
Neji, Lee, Sai (AND MAYBE SHIKAMARU) vs Tsunade
since Tsunade got this UBER STAMINA THING, she would be fresh and ready to continue fighting.......... But the others? (with the exception of probably lee)
I give it to Tsunade mid difficulty