The problem being he needs to get close to Tsunade. But Tsunade's heavenly Foot of Pain is in itself a mid-ranged attack. The shockwaves are strong enough to break buildings.She uses chakra for her regeneration jutsu. So if Neji block her chakra system. It's over. And he is faster than Tsunade and has Byakugan and kaiten to protect himself in close combat if it's needed. That's why i say Neji can solo.
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It kinda seems like a skill a medical ninja should know how to open and close chakra points. I mean yes the Hyuga Clan specializes in fighting that way but Medical Ninja should be able to save a person whose chakra points were closed via reopening them as their closing of chakra points is merely using the right amount of chakra to stimulate the point into closing.