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If Tsunade has the reaction and speed feats that rival the paths then she can avoid FRS.
FRS is basically a larger version of a Fuma Shurikan, are fuma shurikans fast? No. You know that move is slow when you can simply jump out of the way and when it expands jump again.
SM Naruto can throw the FRS, base Naruto can't. So your first point is irrelevant.