I find it funny how people think all genjustu are the same and tsunade can break any form of genjutsu. Ive already acknowledged that any form of genjutsu that isnt derived from the sharingan would be broken by a medic with high chakra control however sharingan genjutsu, is harder to break medic or not;
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Orochimaru was stuck in a paralysis genjutsu and he was in the middle of breaking free however there was enough time for itachi to severe his hand before he did because he was paralysed and in that state its harder to break free. May i also say orochimaru is a chakra control expert if he gets a 5/5 for genjutsu. Moral of the story paralysis genjutsu would get the better of tsunade. How will itachi kill her?. There should be enough time to take her head off. Wonder whether Tsunade's fans will confuse her medic prowess to immortality and claim she can pull off a hidan.
Again i hate to sound like minato fans, but Tusnade just isnt hitting itachi. Not with a speed of 3. Secondly her main fighting style is taijutsu, id like to see her fight like that whilsnt not maintain eye contact. Sharingan or any form of bunshin isnt needed to evade Tsunade.
May i also say that itachi can launch numerous ninjutsu attacks that she will not be able to evade due to his handspeed. She might not die, but she would constantly need to recover and this ability to recover is from the use of chakra. If she runs out of chakra due to healing her injuries a time would come when an attack could kill her if she has run out of chakra to heal herself