Tsunade wins: sasuke has less chakra than tsunade... Tsunade has katsuya( high resistance n high endurance), sasuke can't get past katsuya( one clone stated on naruto through his nine tails rampage!!!!) Kirin n any other lightning jutsu sasuke has wont hurt tsunade.... Tsunade has unsurpassed taijutsu.. High healing n high regeneration jutsu... Craziii. Sasuke wouldn't beat tsunade.. He's b a goner as soon as tsunade use her lightning style, disrupts his electrical signals, n leaves him disorie Ted on the floor. She has chakra dissection blade which even further damages sasuke.. N with healing ability.. Sasuke loses.... Sasuke's Amaterasu can b sealed if it hits katsuya( or one of her clones) .. Also, if it hits tsunade, sealingvwontvb necceaseary, her regeneration jutsu is very high in recovery, so Amaterasu would b useless after it destroys the first layer of tsunades bodi, only to regenerate right after n even during...... Sasuke loses from one direct hit of tsunades taijutsu, chakra blade, or lightning style jutsu.