Here's the problem. We haven't seen Tsunade's limit on strength yet so let's not say what her strength can't do.The Uchiha brothers take this with mid to high difficulty.
Itachi has already wrecked Orochimaru twice with once using only genjutsu. None of the sannin have the necessary speed to dodge amaterasu and it takes Jiraiya time to use SM.
None of the sannin have the necessary destructive power to break through a full susanoo especially Itachi's with the yata mirror. Tsunade only broke the rib cage susanoo, so don't use that as an example. Then there's also Sasuke's enton manipulation he can use with his full susanoo not to mention he can also use it to cover his susanoo as well.
Then there's genjutsu as well, which is a huge weakness for Orochimaru.
The sannin just don't have the fire power to take these two down.
Secondly, Full Susanoo does not protect from underground and there is an Earth User on this team capable of making a Swamp of the Underworld capable of sinking Manda when his chakra was only at 30 percent. And capable of doing a fire tech that dwarfed Katsuya, Gamabunta, and Manda.
Tsunade and Orochimaru can stall for Jiraiya to prepare Sage Mode. In the meantime he has many other frog summons to fight and help stall while he prepares SM.
Susanoo has 4 weaknesses we know of. The ground, brute strength, extreme heat, and acid. The Sannin have every one of those. The Ground and Heat goes to Jiraiya (Earth release, and he has fire techs such as Toad Oil Flame Bullet and Goemon). Tsunade has the brute strength and the acid via katsuya.
Obviously, the next argument to come up is Genjutsu. But consider this Jiraiya has at least 4 summons he has used in battle and another one he was going to use against kisame, there is katsuyu, Manda, Orochimaru, Jiraiya and Tsunade. That is 10 beings that must be caught in genjutsu at once. If the bros don't watch the sannin they'd break out themselves, but if they keep an eye on the sannin the summons can insert chakra into those affected by genjutsu or physically hurt them to get out of genjutsu. In fact if a mini katsuyu is on everyone's back like a leech she'd only have to insert chakra or do a mini acid. If they go for the controlling the summons then the sannin will just release them from the genjutsu. If everyone on team Sannin, summons included had a Katsuyu on their back while the rest of Katsuyu did battle, if katsuyu got caught anyone can save her and if anyone else got katsuyu could save them.
After genjutsu their is the threat of Amaterasu. That's always the next line of defense. Say they do hit a sannin with it. Orochimaru sheds his skin. Hitting Tsunade with it is a bad idea because the next time she goes to attack them, they'd be screwed trying to put out the black flames she just put on them. If you think well Susanoo will protect them, the flames that were on Sasuke's susanoo were not attacking it but as Mei's lava showed, Susanoo melts and if the black flames are attacking and the flames are hotter than Mei's lava Susanoo will melt and the bros will still be screwed. Amaterasu suppression seems like it takes a lot out of you based on Sasuke's response when he fought Bee. You may argue she'd be in too much Pain to fight back. But I don't think so. She was completely impaled and continued to fight, 3 yasaka magatamas at point blank range didn't stop her, nor did hemophobia in conjunction with the sword of kusanagi's three wounds and Kabuto cutting her abdomen, respiratory, and bicep muscles. Which leaves Jiraiya its a well known fact that Jiraiya has fire seals. We also know that a regular katon can fight Amaterasu because Sasuke did it. This is speculation and isn't really included in my argument but jiraiya took those flames for research he may have found there weakness as Itachi says every jutsu has a weakness and he is amaterasu user. So spamming Amaterasu would be a lost cause here. End of the speculation disclaimer. In addition Sage Mode allows you to sense and Jiraiya would sense speedy attacks and thanks to his reflex boost from SM be able to dodge in all likelihood. Which brings us to Susanoo arrows. Orochimaru has his Rashoumon Gates, Body Shedding, Gathering of Snakes, and Slithering Snake. Jiraiya has his sensing and his reflexes and Tsunade has her Byakougou. Oro has info on Itachi, and sasuke's abilities are really only that of Itachi's sense they are the same eyes.
Let's not forget Jiraiya's unnamed Barrier that IIRC took out the human path. Should someone mistakenly enter it, they die. The bros can't just safely sit in Susanoo and win. If they come to use taijutsu against Jiraiya and don't know about the barrier, one of them dies. 1 vs the 3 will lose.
EDIT: Sasuke really can't have EMS if Itachi has MS and is living...just something I noticed. Not that we've seen much from EMS Sasuke.
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