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Her medical ninjutsu can't deal with it, that is true.
Her regeneration jutsu is a different story. Tsunade even stated the first time she used sozo saisei that it's not medical ninjutsu, but a regeneration technique. There is absolutely no logical reasons why Tsunade wouldn't be able to regenerate herself after being hit by a rasenshuriken.
Any regeneration, or healing of a wound is cellular level. :|
Byakugo no jutsu is almost instant as well. Rasenshuriken does not produce any projectiles that could get stuck to the person it hit, this is why Tsunade's regeneration jutsu can in fact heal the damage pretty easily, as they're all just miniature stings that heal immediately because of the byakugo no jutsu.
Doesn't matter. It separates the chakra tubes, meaning the part that the tube won't be able to regenerate since the regeneration jutsu won't be able to effect it.