Except Naruto:
1. Is a Jinchuuriki, which by itself already makes him pretty UNIQUE.
2. Spawns Kage Bunshins like crazy, which nobody else does - UNIQUE again.
3. Rasenshuriken, UNIQUE to the top.
Sakura is a Tsunade's clone in almost EVERYTHING, especially more than certainly in JUTSUS.
She didn't INVENT anything that'd make her UNIQUE (I doubt that Poison Extractor is that much different from the general Medical Jutsu applications; the rest of her jutsus are merely PUNCHES and/or KICKS with different NAMES, zilch UNIQUENESS about it).
No, it doesn't. As if that brought any change in his overall personality. The major theme was isolation from the rest, a theme repeated through Jiraiya as he was not as bright as the other two, spend a large portion of his life travelling, Obito as he was an orphan like him, a failure in the academy, and Hashirama because he was different from his clan on his stance towards the Uchiha. His own father didn't take kindly to his protests about blood-shed. What the factors behind it were is an irrelevant point when the main theme remains the same in all three characters.
I can't believe you are serious with the other two when they have literally no impact on his personality whatsoever. There is only one clan has has literary merit through the techniques and they add to their character development and that is the Uchiha Clan and then after a vast difference the Hyugas because of the branch and head family differences.
What makes Naruto unique in terms of personality? Which technique did he invent himself? Oh wait, he didn't invent anything. Rasangan: he learned it from Jiraiya. FRS: he learned it through Kakashi's training. Mass KBs, there are several ninjas who can make KBs. Their number is something Kurama allowed him.
Let's see how this parallels. Jiraiya learned Rasangan and SM. Naruto did the same. His father died before completing FRS or infusing some other element with Rasangan, Naruto succeeded by cutting down the training time of several long years to a couple of days. That makes him a clone of two people through techniques alone. FRS is unique to Naruto like Intangibility was to Obito. I still see no point, given that when the whole themes are brought into focus, he's the most cloned character in the entire manga. It's almost disgusting.
You should work on getting your eyes checked by a doctor.
You should work on your intellectual capacity to process basic themes ... my mistake, as the biological damage is done for life. I cannot believe anyone can be this stupid to deny the in-your-face similarities between these characters.