Madara, Izuna, Sasuke killed the persons closest to them (well techniqually Sasuke didn't kill Itachi but it was basically that way). We don't know about Kakashi (odds are he didn't), or Shisui (idk on that entirly) so most in that category have killed their closest person.
People defeat steriotypes, however we've only seen Itachi, and Shisui defeat such steriotypes in a clan of hundreds possibly so it's safe to say that the Uchihas still bare their hatred, even in death, for the Senju. Sasuke was a young child and everybody is innocent as a child so, no old Sasuke wasn't an exception. Sasuke inherited the same curse of the rest of the clan, hatred and revenge.
The concept of the Uchiha (from what has been explained) is that they were bred from hatred and they bare the "Curse of Hatred" (or something like that, can't remember the actual quote) as stated by Madara and it's always directed towards the obsession of higher power to usurp power and defeat the Senju.
this
and it's time to end this so called "debate"