Hashirama's cells mean jack in this matchup. Madara had Hashirama cells when he lost his arm against the bijuu and
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. Couple that with the fact that not even Tsunade has shown the ability to regenerate lost limbs and it is quite apparent that Hashirama's regeneration can be overcome, quite easily, by someone who can make
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, and
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to the Juubi's Jinchuriki. That's not even considering the fact that the Madara being discussed in this matchup is basically Madara - SM durability and the Juubi, meaning his durability against Guy's attacks will be nonexistent.
People seem to forget how fast Guy is now too. Madara did not have enough time to manifest any version of Susano'o when the
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. As a Jinchuriki he
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a
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. Guy in Gate 7 fought hand to hand with that version of Madara and was outright blitzing him in 8th Gate, yet a vastly weaker version of Madara is going to manifest Susano'o, much less Perfect Susano'o (which has to be
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) before taking an Evening Elephant?
Here is how this match is going to happen: Madara is going to note that his opponent has red steam, before being slammed into a mile deep hole. Guy then follows up with 3 or 4 more Evening Elephants for good measure, thoroughly reducing Madara to paste. There's a slim chance that Madara may be able to manifest a Susano'o ribcage before getting hit, even a miniscule chance that he could manifest a V2/V3 Susano'o. They get overwhelmed with Evening Elephant, and then Madara dies soon afterwards. Guy wins.