I want to ask you how can Sasuke dodge Hiraishingiri if Tobirama use it on the start of battle.
Tobirama is creator of Kage Bunshin, so if he creates multi-Kage Bunshin that attack Sasuke, he wouldn't use Susano'o so fast. I think he would fight to clones in Taijutsu maybe he uses some Ninjutsu...