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One of the translators in narutoforums takL expressed doubts about the fidelity of the translation of Orochimaru's words in Ch. 616 p1 He says that Sasuke is possibly not really annoyed with Naruto but instead it evoked a concern emotion from Sasuke, at least accdg. to Orochimaru:
They are best friends, no matter how anybody tries to put it that is part of the theme of this manga.
It's all a matter of interpretation.