For TSUKUYOMI, first Itachi needs to aim at their eyes, and that's not an easy task. specially when you face a speed monster such as oro, and like i said before, with a Tsunade using Katsuyu to dispel chakra regularly, Genjutsu SPECIALLY TSUKUYOMI would be a hard task as for oro. Jiraiya, you still need to aim at his eyes to make him fall in Tsukuyomi and with katsuyu giving chakra it is still easy to break NORMAL GENJUTSU.(Sasuke's) Tsukuyomi - Can at least catch them in it for a little while. Just enough to throw them off.
(Sasuke's) Susanoo - Danzo had to use a summon and an A rank wind jutsu to make a hole in an incomplete Susanoo. Afterwards he got the completed version against Kakashi but he went blind. So an almost absolute defense with very fast arrows. Fast enough so Kakashi couldn't dodge.
(Itachi's) Susanoo - unbeatable as long as it is up. He has the ultimate defense with the Yata mirror and the Totsuka sword. All of the summoning would easily be sealed with Itachi's Susanoo. aPlus you can't hurt him while in there.
(Itachi's) Tsukuyomi - Unbeatable, no one can break out of it except for Sasuke or possibly Madara, immense trauma to the brain and body. It only lasts one second so how are they going to defend against this? Look at his feet the whole time? That leads to my next point.
(Both) Amaterasu - Only Oro has a defense against this as he can regenerate any body part if he cuts off the burning part. If Jiraiya or Tsunade is hit they are done for or they can cut off their limbs, without which they would lose easily. And if they don't look at Itachi's or Sasuke's eyes then they can't see if Amaterasu is coming can they? NO
Itachi's regular genjutsu - Strong enough to beat Oro, and Deidara, and Sasuke with. How can they break out of a genjutsu if they don't know that they are in it? Answer me that. And don't say oh the others can break them out because guess what? They would either be in a genjutsu or not know that their teammate was in one. What are they going to do, hold hands to check their chakras?
Fire jutsu - The Uchiha are fire masters and only Jiraiya uses fire as well, Oro uses wind which guess what? Is weak to fire. Tsunade has not shown any elements yet I think.
Speed - Both Itachi and Sasuke are normally faster than any of the Sannin, Itachi is way way faster than them. Plus they have the sharingan which helps a ton in taijutsu. If you don't believe me look up the normal sharingan abilities.
Sharingan bonuses - ability to copy and memorize jutsu, and see chakra, and track movement, and predict where the opponent will be.
Chakra - Sasuke has alot, Itachi apparently had more than Sasuke did even with his Curse Mark and Itachi was sick. So no BS about Itachi having low chakra.
Intelligence - Itachi is easily the smartest of the five with Jiraiya and Oro probably coming in second and third. In battle I would think Sasuke is smarter than Tsunade.
Summonings - Slug, Snake, Toad, Hawk. However the summonings don't really factor in as they could be beaten easily with Susanoo. No way are any of the toads or Katsuya faster than Kakashi and he couldn't dodge that Susanoo arrow and Itachi has the Totsuka sword which is an automatic seal if it pierces you at all. One slash and you are toast.
And I read some posts saying that Tsunade can heal people from the damage from Tsukuyomi. How fast do you think she can do that? If it isn't instantly then she would pretty much be toast because neither Sasuke or Itachi is going to let her sit there and heal them. In fact her healing abilities wouldn't make any difference at all unless everyone decided to take a break and sit there and rest. Because I know she can't heal them in the middle of fighting. It is unrealistic and the people who think that it would happen are deluding themselves
Tsunade wouldn't be able to do a single thing against either Itachi or Sasuke, they have the sharingan which tracks movement and predicts it, so her super strength counts for nothing if she can't hit him. And if a weak Kabuto from Part 1 can avoid her hits then Sasuke and Itachi easily can.
Jiraiya the only argument coming from this corner is that Itachi said he would stalemate against him. Which we all know is total BS. His weakness is genjutsu and Itachi is a master of it. None of the Sannin have a defense against genjutsu and there is no way to know if your partner is in a genjutsu unless they start doing weird stuff. Plus Itachi has Amaterasu which Jiraiya has no defense against unless he wants to start tearing off body parts.
Orochimaru, his main weakness is cockiness and genjutsu. He is the only one with a defense against Amaterasu but Itachi would still wreck him. Or Sasuke with MS, I don't know if anybody saw Itachi fight Oro (twice) but he beat him both times withing seconds and one of those times he was dying of disease and out of chakra. Plus his element is wind and wind is weak against fire (something both Sasuke and itachi are proficient with).
Make valid counterarguments please. DO IT. How would the Sannin win? They can't beat them. A more valid battle would be Itachi vs. the Sannin or Sasuke vs. any combination of two of the Sannin, then they might stand a chance.
EDIT: And I also read that someone thinks Tsunade has a defense against Amaterasu, well you would be wrong. She can heal herself but that uses a ton of her chakra and Amaterasu doesn't stop burning until whatever it touches is completely burnt. So healing herself after she was burnt to a crisp wouldn't do much good, and healing herself while it was still burning would be useless as the Amaterasu would still be burning her. It isn't like it is just going to go out on it's own. Jiraiya could seal it but that takes alot of time which either Sasuke or Itachi would use to kill the two of them.
So yeah Jiraiya and Tsunade still don't have a defense against Amaterasu or Tsukuyomi, other than dodging and looking away from their eyes which would make them susceptible to either one or the other of those two MS techniques.
If they dodge Amaterasu they are more likely to accidentally make eye contact as they are struggling to dodge, if they look at their feet to avoid eye contact they will never see Amaterasu coming and so would be finished either way. That is why it the MS is so powerful, you have to be either incredibly fast or be an Uchiha named Sasuke so you can brave Tsukuyomi and break out of it.
For Sasuke's Susanoo, you just said it, It took one summon and A rank wind ninjutsu. BUT CHECK OUT THAT WE ARE TALKING ABOUT 3 BIG FROGS, 1 MANDA, 1 YAMATA OROCH, 1 ACID THROWING (AND AS SEEN ON MIZUKAGE VS SASUKE FIGHT) susanoo bones can be melted.
For Itachi Susanoo, if it is that almighty, how can he block dark swamp jutsu?
, IF HE JUMPS HE IS EASY TARGET IN MID AIR. And including the fact that it's not only 3 sannins but all of their summons. Tsunade through katsuyu constantly infusing chakra to the summons and sannins can prevent genjutsu from controlling them. Susanoo is just like an extension of the caster himself. So it is still 2 vs sannins and all of their summons (pretty hard fight if you tell me)
Amaterasu, oro has his technique to escape from it. Tsunade has her Souzo Saisei. Enough to heal her while she burns, giving her enough time to at least catch one of the two bros and with just touching one of them the fire will be passed too. Remember we are counting the summons too, and that amaterasu simply destroys BIG portion of chakra which they don't have. Like it was said before in Naruto season 2 I think it was when Itachi WAS HEALTHY, He could only use 2 Tsukuyomi and 1 amaterasu. In Naruto shippuden when fighting Sasuke he could only do 1 Tsukuyomi and two amaterasu. One big one that followed sasuke, 1 that countered sasuke's katon jutsu. So they don't have a chance to spam it easily now that they need their chakra seriously.
Chakra? too bad Sasuke doesn't has his Curse Mark anymore. Itachi chakra we already know it's limits. INCLUDING BOTH OF THE BROTHER'S STAMINA.
Intelligence: remember we are talking about teamwork and in separate they are pretty much the best but together?? The sannins are known for their teamwork. So they basically know each other well and how to get their moves get together well.
OH YES SUMMONS PLAY A BIG ROLE HERE. They not only act as decoys, Genjutsu Releaser (Katsuyu), BUT A BIG OFFENSIVE. What happens if Manda attacks from below?? DONT TELL ME YATA MIRROR CAN BE PUT ON SUSANOO'S FOOT. The summons can hold the susanoo's letting jiraiya use dark swamp on both susanoos. STATE AN SCENARIO. Wait you are sealing each summon? remember sealing takes time, IT IS NOT INSTANT, As seen when Susanoo absorbed Yamata Oroch.
Tsunade, surely is not fast enough, BUT SHE CAN CHEAP SHOT THEM from behind while they are fighting oro, jiraiya and summons. Her main role here is to support agaisn't genjutsu and heal.
Jiraiya, if he's fighting agaisn't itachi. Last time he saw Itachi he used a scroll to seal amaterasu, Jiraiya since this point, may know that to fight itachi he may need many of this scrolls. Genjutsu, COMING BACK TO THE KATSUYU GENJUTSU DISPELLER.
Orochimaru, as already stated the only genjutsu that will work is Tsukuyomi, thanks to a katsuyu genjutsu dispeller. Wind jutsus are oros and he knowing this do you think he will try fighting fire with wind? He will most likely use his edo tenseis WHICH NOW APPLY IN THE SPACE OF SUMMONS, and his kusanagi to attack the bros, REMEMBER ORO HAS FIRE NINJUTSU TOO.
Yes, Tsunade can heal herself from amaterasu AND DEFINETELY IT WILL LAST FOR LONG!!!!! Her chakra is INMENSIVE I would say that even BIGGER THAN ORO'S AND JIRAIYA WHO ARE CHAKRA BEASTS. Proof?? She healed, Protected her whole village from a Chou Shinra Tensei, and healed her whole village through katsuyu. And she can last long enough to receive 4 of those amaterasu shots and heal herself and get Jiraiya to seal them with his scrolls.
Yes they are struggling and do you think that sasuke and itachi can separate themselves from susanoo and leave them fighting the summons? SIMPLY NOT, Susanoo is an extension of the caster so it's not like the summons will let the two brothers be able to roam around.
Susanoo is so perfect BUT LIKE ITACHI HIMSELF SAID EVERY TECHNIQUE HAS A WEAKNESS:
* It doesn't protects from below: Dark Swamp jutsu, Oro millions of snakes vomiting, A acid lake provoked by Katsuyu miniature version spitting acid all over the place, Manda coming from below the ground.
*It puts strain on the caster. This surely destroys the little stamina the two brothers have.
SO, stop acting like summons are fodders, sannins can't do a thing. In this battle the uchiha bros are simply outnumbered, and outclassed by the teamwork the 3 sannins can do BECAUSE THEY ARE EXPERTS IN IT. While the 2 bros will most likely fight 1 by 1 instead of teamworking, since MANGEKYO SHARINGAN ATTACKS ARE NOT MADE FOR TEAMWORK BUT TO SOLO.
Have I Made your wish for an answer to your post COME TRUE?
I'm open to debate everytime you want