Considering madara couldn't i highly doubt Itachi couldBut that's the best part. it does matter, the fact that non killing intent itachi was able to put folks in gen before realizing left them vulnerable long enough for itachi to of long killed them. sensory skills isn't going to work on itachi. :lol
Hashirama speed literally and raction dwarves him
But he would easily reacts to Itachi's each and every movement consider madara with his SM was able to react to Tobirama who marked a JJ multiple time in fraction of secondssensory skills won't see his gen coming