Just saw these gifs for when Itachi reacted to Shisui jumping off that cliff and committing suicide. I know that this may seem like a dead topic (because the Kakashi Anbu arc is over & we all stopped discussing it a while ago) and it's not a happy one to bring up, but I just saw them this morning and felt the need to post them.
You must be registered for see images
You must be registered for see images
As we know, he didn't actually say that. It was more like "Shisui, don't" and then Shisui jumped as Itachi reached out in the second gif and had that look of horror on his face while saying nothing. He wasn't concerned about the Uchiha/Konoha mess at that specific moment obviously (moreso directly about his best friend being in pain and losing his life), but later on in the arc we see him pondering the correct choice to make and asking Kakashi about the promise he has to keep for Obito, so I feel that these two gifs represent a little of the desperation Itachi felt with the situation he was in after Shisui's death.