I proved that at 100 m distance and no Katsuyu, Temari could solo Tsunade. (
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I made a thread with similar conditions but with Shino instead of Temari and even the likes of TheEvilOne and Tazilla88 agreed that Shino would win. (
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Also there are multiple threads where it's been proven that Tsunade would lose to Neji without Katsuyu. Due to the fact that there are all sorts of CQC fighters and long ranged fighters in this fight, the long range fighters can easily escape Tsunade's range.
Byakogou isn't tanking gentle fist, chakra loss from Shino's bugs or getting sliced to bits by Kiba or Temari. Pretty sure Sakura's punch would also incapacitate Tsunade but that is debatable. As for Katsuyu... well let us just say that its acid gets blown away by Temari right back at Tsunade. Furthermore, if Tsunade or Sakura do summon the slug, its huge shadow will give Shikamaru the ability to capture Tsunade and slow her down occasionally.
I'm going to have to say team 2 low difficulty.