Issho mentioned that he wants to see the Shichibukai system eradicated. Do you think this will happen in the story (discounting the EoS scenario)?
If possible, please provide a brief explanation of why you think so.
MY INPUT:
Yes. The World Government will start a major offensive against all PIRATES at some point including the Shichibukai. They were meant to be a temporary increase in power until the Pacifista project is finished which they hope will be enough of a power boost to conquer the NW.
Shichibukai are a risk that they don't have to take at this point. They'll have to vanish like every PIRATE out there to demonstrate the power of the WG.