The last two chapters have had plenty of filler about the Fruit Tree and how Karma works, but they've given us two plot points that definitely won't be neglected.
1. Isshiki was maimed by Kaguya. Supposedly, he was betrayed; though, it's possible Isshiki intended on betraying Kaguya beforehand. We don't know the details, but we obviously will eventually.
2. Isshiki is attached to Jigen's brain and controlling him. Apparently, he is actually, as in LITERALLY, still on Jigen's brain. This point is 100% relevant to the plot because it's being forced in. The explanation for why Jigen is there is because he was too weakened to place the seal. Do you know how Momoshiki gave his seal? After literally being disintegrated....
Point 1 means we need someone to explain why Kaguya attacked Isshiki, then Point 2 gives us that person. Ike could have allowed Isshiki to completely merge with Jigen's body, but Isshiki is still physically there. The setup for the two to be completely separated is already laid. Jigen is the person who'll explain what happened. As a bystander(?), AND as a monk that potentially worshiped Kaguya, aka, The Rabbit Goddess he'd know something. Sakura removes Isshiki from his brain
.
The big stepping stone to reach Point 2 is Isshiki's defeat. Does Kashin defeat him now? Doubtful. Jigen's body needs to be intact and Kashin is literally frying the man RN. Amado is also being set up to stick around in the Leaf, which would be somewhat unnecessary if Isshiki dies to Kashin. As it looks, the plot will move on through Amado after Kashin's failure to kill Isshiki.
Points that are related to Amado:
How does he have a Jiraiya/Naruto(?) clone?
Who Delta is to him.
How to truly kill the aliens.(Not relevant because it's going to be addressed next chapter)
Kawaki(mutual interest in ridding of Karma).
I'll choose the plotline that involves Kawaki. If Kawaki/Boruto were to kill Isshiki, all would be solved(ignoring their Karma marks). Personal issues have to be sparked up, and Jigen is the only one with that capability. What would spark it back up? There's plenty, and probably more reasonable, theories that fit in place, but I want you to consider what I think is the most interesting.
TL;DR & continuation of the thread:
1. Isshiki was maimed by Kaguya. Supposedly, he was betrayed; though, it's possible Isshiki intended on betraying Kaguya beforehand. We don't know the details, but we obviously will eventually.
2. Isshiki is attached to Jigen's brain and controlling him. Apparently, he is actually, as in LITERALLY, still on Jigen's brain. This point is 100% relevant to the plot because it's being forced in. The explanation for why Jigen is there is because he was too weakened to place the seal. Do you know how Momoshiki gave his seal? After literally being disintegrated....
Point 1 means we need someone to explain why Kaguya attacked Isshiki, then Point 2 gives us that person. Ike could have allowed Isshiki to completely merge with Jigen's body, but Isshiki is still physically there. The setup for the two to be completely separated is already laid. Jigen is the person who'll explain what happened. As a bystander(?), AND as a monk that potentially worshiped Kaguya, aka, The Rabbit Goddess he'd know something. Sakura removes Isshiki from his brain

The big stepping stone to reach Point 2 is Isshiki's defeat. Does Kashin defeat him now? Doubtful. Jigen's body needs to be intact and Kashin is literally frying the man RN. Amado is also being set up to stick around in the Leaf, which would be somewhat unnecessary if Isshiki dies to Kashin. As it looks, the plot will move on through Amado after Kashin's failure to kill Isshiki.
Points that are related to Amado:
How does he have a Jiraiya/Naruto(?) clone?
Who Delta is to him.
Kawaki(mutual interest in ridding of Karma).
I'll choose the plotline that involves Kawaki. If Kawaki/Boruto were to kill Isshiki, all would be solved(ignoring their Karma marks). Personal issues have to be sparked up, and Jigen is the only one with that capability. What would spark it back up? There's plenty, and probably more reasonable, theories that fit in place, but I want you to consider what I think is the most interesting.
TL;DR & continuation of the thread:
What if Isshiki is actually the hero of Shinobi? He's gone all these years without bothering for a vessel until now. Why? What if he was actually content with the 1,000 years of warring? I believe Isshiki was popular among the populace when he ruled alongside Kaguya and that he had their backing. What did Kaguya want? Peace. Isshiki? Chaos. I think Isshiki, backed by Shinobi, challenged Kaguya's rule. After eating the fruit to do so, Kaguya probably became rebranded as a demon once she crushed Isshiki and his supporters. Kaguya wanted to reclaim all chakra? Perhaps she was actually bent on destroying Shinobi.
If such were the case, it'd mean Shinobi are the actual cause of the 1,000 year war.