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Well since you so condescendingly asked, limbs cannot be regrown. Since the seal's only function is to hasten the effects of the natural enzymes in our body that creates cell division. But alas our body wouldn't naturally regrow limbs since those are human extremities. Organs on the other hand can be regrown by the body naturally to a certain extent I.e. part of your liver(and said extent is vastly extended during the use of that technique.) That's likely why or had her legs reattached to her(which can be done irl just at a smaller extent) instead of growing new legs.
Another thing to note is that the seal doesn't remove old cells or poison. Since neither has anything to do wit cell reproduction. So without an antidote it in fact speeds up the rate in which poison travels throughout the body. Anything else?
Yet Tsunade said it, and it's naruto they don't obey all logic, juubi madara regenerated an arm. And you're proving exactly what im talking about that you all think you can outwit the manga with real world knowledge, also what does poison have to do with now? We already know Tsunade solos poison anyways.
Regrowing limbs would exhaust reserves anyways as stated in a thread of my byakugou analysis. My only peeve is the brain thing because based on manga stated things noone would question that just because they feel it shouldn't because of the 'real life logic'
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