Though not particularly fazed about which fictional character ends up with who or any of that nonsense, i believe Sasuke and Sakura are the most likely relationship in the manga. In fact that was the very first hint of any sort of relationship that the manga has given us. Its cannon that apart from Mikoto, Sasuke's mom, the only other female that sasuke has shown some form of affection/consideration towards is sakura.
- Their first ever mission he protected her.
- Against haku/zabuza we was asking what kakashi is doing when sakura was screaming in fear
- The chunnin exam where she took care of both him and naruto and when he woke up and the cm took over, only she could subdue his rage
- Protected her from Gaara when she was about fall
- When he was leaving he did say thank you which is a big thing for somebody like sasuke and because he knew she would follow him/couldnt bare see him leave, he knocked her out xd. Nothing hard though
She has also should care towards him however that is very clear. Anyway Sasuke has always liked Sakura and i believe if Itachi didnt show up, he wouldve eventually shown his other side an subdue to his feelings. Even now though its hard for others to believe, i still think that sasuke still likes her. He is just confused