Slender Man
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Naruto managed to eventually TNJ Obito.
The Kages got their ass handed to them.
Izanami trolled Kabuto and his army.
So all we're left with is Madara. It's easy to assume Sasuke will land the critical blow, but there is a good chance it will be someone in the Gokage.
Look at Gaara for example -- he did a decent job against Madara even though he is no match. This could be Kishimoto foreshadowing that the Gokage is about to get their revenge.