Itachi, and it's not even a contest. Minato's best feat is the one where he analyzed the TSBs. That's it. One feat doesn't make him superior than the slew of analyses and battle tactics Itachi came up with in the manga. He's wanked to hell for no reason at all.
Looks like you're as dumb as your fave...
Obito had Hashirama's DNA/Chakra so his Chakra Signature was messed up, try again kiddo...
He had White Zetsu Cells, not Hashirama cells. Half his body is literally made out of it. We were even shown one of the hollowed out White Zetsus, which would explain why Obito doesn't ever seem to tire out, nor his eye experiences the MS setbacks:
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- Zetsu carved out for Obito’s body.
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- Zetsus surviving for a long time without food.
So no, there was no "chakra signature" mess up. His sensing is, canonically, shitty as hell.