Where did Itachi get his illness from?

SenseiSama

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His chakra was responsible, Karin noted that Sasuke's chakra was as strong as CS level 2 meaning MS users have the same chakra potency as Senjutsu.

Since Itachi's chakra were strong enough to grant Sasuke EMS it wouldn't be a stretch to say his body was unable to handle the power of his eyes, Oro's students noted how CS can corrode the body and coincidentally BZ made a remark that Itachi's body was being eaten out from the inside.
 
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Before Itachi had a fight with Sasuke, Tobidara tried to kill Itachi and they both had a fight, which ultimately led to Tobidara's defeat, but Itachi was still severely injured/exhausted from that fight. And right after that the latter procceeded to fight Sasuke later on.




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