Where did Itachi get his illness from?

Ricardo

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It was probably a side effect of overusing his Mangekyou Sharingan.

Sasuke stated that every body cell hurt while using Susano'o, by that time, Sasuke only had a humanoid incomplete skeleton version.

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Itachi already by that point mastered his Susano'o to his limitations.

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Aquaglow

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It was probably a side effect of overusing his Mangekyou Sharingan.

Sasuke stated that every body cell hurt while using Susano'o, by that time, Sasuke only had a humanoid incomplete skeleton version.

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Itachi already by that point mastered his Susano'o to his limitations.

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He was referring to his sickness! Itachi was already sick and he had to use susanoo!
 

ANiMUS

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Stress from guilt, tormented by the screams of his dead family and comrades night and day probably wore on him. Itachi was such a kind child U_U

You add physical stress from using MS to the stress from his guilt and it eventually led to his end
 
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Michael

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Rumor has it he and shisui engaged is sexual activities on a daily. Sometime during those events itachi contracted aids, shisui felt guilty and offed himself and itachi ran away from home due to guilt. :sigar:
 
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