there is pretty much no way he will come back and they keep having people talk to naruto, telling him to give up on sasuke but he refuses to. the fact that he refuses to means that sasuke will probably die because that would make it more dramatic. unless something comes about that would change what sasuke wants (the only thing i can think of would be finding out that the leaf didn't actually order the genocide), he is doomed to die because he is going up against naruto, naruto is the main character and the fight would be a fight to the death.