Tsunade vs. Kakashi

[Blaze Release]

Kakashi has what it takes to beat her and tbh its very close between the two.
Id give it to Tsunade with high difficulty

 

[naruttebayo]

tsunade wins

 

[Tazzilla88]

Now analyze Kakashi's abilities.. and make a conclusion.

If you so wish. Kakashi's signature moves include Raikiri and Kamui. He has not been shown using Kamui expertly yet. But we know that three uses of kamui = dead Kakashi and 4 raikiri = dead kakashi. Which means Kamui is a last resort for Kakashi. He has shown good trap setting skills with is lightening clones. Such as when he tricked one of pein's paths. He was capable of dodging Sakura though that isn't a very large feat as she didn't use and kicks or major ground strikes. He can ready movements with his sharigan but that takes an extra toll on him not being an uchiha. He carries no long weapons. Kakashi does have long range attacks via water dragon jutsu and his lightening hounds.

Tsunade strength is unparalleled. Kakashi wasn't much more dodgy than Kabuto and Kabuto took a blood pill to aid him in the battle because Tsunade had cornered him. Orochimaru was able to keep up with 4 tails Naruto but after three hits from Tsunade called it quits iirc. In addition she has her chakra scapels, Katsuya, her disruption technique, her healing techniques, huge chakra reserves and the ability to alter the batttlefield with pure strength. Plus this

I think we are underrating Tsunade's intelligence here. She's brilliant really, even beyond her medical field. Take the war with Pein for instance, she strategically sent Naruto away to get stronger rather than following the advice the advisers, rather than taking pein head on, she healed the entire village, she had Katsuya everywhere that way everyone could gain more info on Pein instantly. In the fight with Madara she devised an attack on Madara so that the other kages could attack him while he responded to her attack. When she was fighting kabuto and her lungs were messed up she pseudoparalyzed him so that she could heal. As per her rules for Medical Ninja she understands the strategies necessary to keep a team alive. She tricked Jiraiya into drinking a substance and played it off perfectly. In short she's not going to stand around and allow any attack. She's going to strategize.

So let's recap. Kakashi uses Lightening blade his hand is trapped in her and she kills him with a punch
Kakashi uses Kamui he may get her but she is a fairly small target that moves in very odd ways.
Kakashi summons ninja dogs... either she kills them or she summons katsuya
Kakashi uses lightening beast runner technique she dodges like she was with kabuto's attacks
kakashi uses lightening cutter he has to get close do so and when he does the technique requires both him and his clone if either is destroyed the technique is over aswell
Kakashi has done basic level genjutsu however people who have precise control over their chakra can stop their chakra and end the genjutsu. In addition to fact that she was able to easily undue to the damage done by Itachi's tsukyomi.
Kakashi's water dragon jutsu may give her some problems but for how long can he hold her off at a long distance. He doesn't combine his attacks so I doubt a water dragon kamui combo is going to happen nor is a lightening beast kamui combo .
Based upon the ease of which she is able to treat sharingan related injuries and she lived during the time in which the Uchiha had their power she is most likely fully informed on the sharingan's power. I am also certaint her grandfather and granduncle would have warned her of the dangers.
Kakashi also does not stray away from taijutsu fights which is to is his detriment. You might say that he knows of Tsunade's strength, true, but he also knew of Sakura's and still went toe to toe with her. Beyond that the only ones who know of Creation Rebirth are Kabuto, Naruto and Shizune. Everyone else is dead or weren't there. And only the four other kage and possibly Kabuto know about Byakougou. Furthermore only Kabuto knows about her body pathway derangement technique.
So against Body Derangement Jutsu Kakashi has nothing
Against Heavenly Kick of Pain he can only dodge
Against her punches he can only dodge
Against Creation Rebirth or Byakougou he has to land Kamui on her head.
Against chakra scapels he has nothing
Against Katsuya who can crush him or melt him he has nothing
You don't blitz Tsunade. Kabuto tried from underground. Raikiri is extremely loud if you remember correctly so he won't sneak up on her with that. She won't fall for headhunter jutsu. And When Tsunade is out for your blood I think we've seen that she stays in constant motion. In addition Kakashi has no idea how durable she is she tanked the Heavenly Transfeer Technique, the Susanoo Sword, the Sowrd of Kusanagi thrice, Yasaka Magatama.
Very Simply Kakashi can't take her on. His one ace in the whole is using Kamui against Tsunade when she doesn't stand still and she fights in awkward positions.

 

[Lankeysob]

The only things that Kakashi has hit with Kamui were going in a straight line or coming straight at him. I thought it would be obvious now after seeing her performance against Madara that she is indeed stronger.

 

[onimarutakeshi]

Tsunade-hime will win for sure.

 

[soulreaper11]

tsunade mid diffcult i dont see kakashi kill her and i think it will come down to who can last the longest and that would be tsunade in charka and stamina