Nope. Orochimaru had no idea what is Tsunade activating:Tsunade finished Byakugou before 50 because Orochimaru said he was familiar with it from the old days. THAT'S HER PRIME.
Kabuto lost to Naruto because of plot armor. Really strong plot armor. Oh yeah and he wasn't a sage back then because he didn't have Jugo's DNA.
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They had knowledge about Jman's SM, but none of them ( except Shizune ) knew what is the Sozo Saizei.
This means she developed the SS when she traveled with Shizune.