He said that "katsuyu can awake her from genjutsu" so it's game over if she gives him a 1 hit ko :flaw::ice: i'm a itachi fan. seriously he can put up a good fight but he will get tired because of his lack of stamina or chakra. Tsunade has a lot chakra or stamina plus she has regeneration ability so i don't see him beat her with 3 tomoes sharingan :shrug: just no wayOne paralysis genjutsu and that's game over.