We havent, I said that because if he did do something to alter his genetic make-up (like infusing himself with zetsu cells) it might help explain why tobi bled white fluid.. Just a opinion though.When have we seen Zetsu bleed white fluid?
Naw chief hes dead, Itachi slit both Mikoto & Fugakus' throats and Sasuke witnessed the whole thing, Fugaku was apart of the Kurama attack that ended in the death of Kushina & Minato thoughAnd it makes sense if you think about it. Itachi and his father never got along very well for some unknown reasons. Maybe Itachi hid the truth from Sasuke.