Ichigo has no chemistry with Orihime at all, she has no personality and is a token big boobed character who is obsessed with the protagonist to make him seem more macho. Her feelings are completely coloured with an immature attraction and she doesn't see him for who he is. Ichigo and Rukia are a much better match, there chemistry is perfect, she has a proper personality and she sees Ichigo for who he really is, her feelings are also mature and genuine but knowing Kubo he will likely end up with Yorouichi just to add shock value, seeing as that is all he is going for in the way of plot now.