We all know that Itachi had Tsukyomi in his left eye...
and Amaterasu from his right eye...
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But, with Sasuke it was different. He had Amaterasu from his left eye...
and Tsukyomi from his right eye...
However, what if Madara has Tsukyomi and Amaterasu in both eyes, like Amaterasu from the left and right and Tsukyomi from the left as well as the right?
That would take a hell lot of strain and maybe that's why he lost his eye-sight so quick. But when he got EMS, he could use both for as much as he wanted but didn't need to. Amaterasu is useless against Hashirama since he has Mokuton. Which would mean, each time Madara spams Amaterasu, Hashirama would use Mokuton as a shield; it would miss Hashirama every time. Tsukyomi would also be useless since Hashirama was supposedly so skilled that he could fight without gazing into Madara's eyes.
Susano was also not needed in the fight against Hashirama since Madara had the Kyubi under his power. However, when the Kyubi was restrained by Hashirama's mokuton, so was Madara xd thus Madara could not summon Susano since he was unable to move. To put it simply, Mokuton + Fuinjutsu are sufficient to overpower and kill Madara.
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and Amaterasu from his right eye...
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But, with Sasuke it was different. He had Amaterasu from his left eye...
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and Tsukyomi from his right eye...
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However, what if Madara has Tsukyomi and Amaterasu in both eyes, like Amaterasu from the left and right and Tsukyomi from the left as well as the right?
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That would take a hell lot of strain and maybe that's why he lost his eye-sight so quick. But when he got EMS, he could use both for as much as he wanted but didn't need to. Amaterasu is useless against Hashirama since he has Mokuton. Which would mean, each time Madara spams Amaterasu, Hashirama would use Mokuton as a shield; it would miss Hashirama every time. Tsukyomi would also be useless since Hashirama was supposedly so skilled that he could fight without gazing into Madara's eyes.
Susano was also not needed in the fight against Hashirama since Madara had the Kyubi under his power. However, when the Kyubi was restrained by Hashirama's mokuton, so was Madara xd thus Madara could not summon Susano since he was unable to move. To put it simply, Mokuton + Fuinjutsu are sufficient to overpower and kill Madara.