itachi has already beat oro in regular genjutsu and every time they fight he losses within seconds.... tsunade will just be hit with amaterusa then the same for j-mann
1: A three man cell is strong because of teamwork and three pair of eyes, hands and feet.
2: This isn't just any three man cell, its three ****ing legendary sannin.
3: Orochimaru is stronger and more twisted than you would know, he would probably be on par with at least Sasuke.
4. Tsunade and Jiraiya would just get hit by "amaterusa" (learn to spell before you try to play smart) ?? Do you think they are stupid? They both know how the Uchiha's jutsu's work very well, and they have TONS of experience. There is no way they would get hit by anything that easilly.
5. Combining the forces of Orochimaru's forbidden jutsu and summons, Tsunade's raw power, summon and healing abilities, and Jiraiya's awesome jutsu's, summon and sage mode would eventually crush the Uchiha brothers.
It wouldn't be a short fight, and it wouldn't be an easy fight. But it would be a victorious fight for the sannin.