Did you see how long a Sick and half blind Itachi Kept Susano'o up:.
When he was talking to sasuke explaing about the Susano'o and mangekyou. blah blah blah
And during ALL the talking They did. And when orochimaru was talking.
And when Itachi was just Standing there. Then when he started walking MAD SLOW. The susano'o was up all that time Even though itachi was sick and on the verge of death already and even managed to reactivate it twice. He did pretty well, for a Sick body.
So just imagine A Healthy Itachi.
He would just slice all of their summonings like he did orochimaru's 8-serpent head jutsu.
Now SASUKE, we've already seen how much he spammed Susano'o.:
Mostly the WHOLE time he was Fighting Raikage, Then when he was fighting Mizukage. Then almost the WHOLE time he was fighting Danzou. So you can't say sasuke cant spam Susano'o. Becuz he Sure did.
And itachi has Yata Mirror which would repel all of their attacks. And the Totsuku blade, which can seal them
And since Sasuke and Itachi have like mostly the same Eye techniques, they should be able to cope with each other. And since itachi's is very smart, he will most liekly figure something out.
Both of their Susano'o are Almost invincible.:
Sasuke's incomplete, 1st form Susano'o was able to protect Sasuke from one of the Raikages Strongest Attacks (Liger Bomb) (Which C Said no one has Ever been able to survive that) So imagine his complete form.
ANd Sasuke can spam the HELL out of those arrows without losing Susano'o, and those must be powerfull Since Danzou Said "If i get hit with one of those attacks im dead" And Jiraiya Don't have Izanagi like Danzou does, So jiraiya would have a HARD time surviving that.
So all Itachi and Sasuke have to Do Is Camp, inside of Susano'o and Spam Amaterasu and Yasaka no Matagam and SAsukes Arrows. And they Both have VERY good control of Amaterasu as seen when Itachi was chasing the hell outta Sasuke with It. And when Sasuke put it around his Susano'o. So its gonna be hell for the sanin to keep running from Amaterasu.
And Tsukiyomi which will most likely be used. Itachis Tsukiyomi will just kill them if he catches them and since It's only 1 second in real life, the other sanin wouldnt even know what happened. And yes Tsukiyomi can kill you.
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(kisame sais "i cant believe he's alive") Although itachi only spared his life, since he was Konoha ninja. So if the Sanin get caught it's over.
Plus none of the Sanin is resistant to Genjutsu, So thats a big advantage for the Uchiha Bros. And breaking a Genjutsu takes time, and you could be dead before that. Although jiraiya has Sage mode, but no one will give him THAT much time.
Really 2 Genjutsu users is just too much so Itachi and Sasuke might win.