all three have mastered summoning, j-man full sage mode, oro Edo Tensei, tsunade creation rebirth, three kage leveled shinobi with exceptional skills as ninjas, tskuyomi has 2 weak sides from the info ive taken from the manga, 1) it uses extremely large amounts of chakra even in a short time of use. 2) avoiding his eyes by looking at his feet or body voids the genjutsu altogether. Itachi was wary of facing Jiraiya, even with Kisame backing him up They waited until they could get Jiraiya away from Naruto, that is saying something dont you think, and your wrong mate, experience counts for most part.
and what makes you think any of them would let sasuke use kirin? and if so Katsuyu there to cover them while healing them in the process, good luck catching those three in eyes site for amaterasu.