Possibly. But than who would be our main female?
Maybe none. There is one candidate that comes to my mind. Now, this will come across as fanboyism to the Sakura fans, but I honestly think that Hinata would be a better main character. I didn't really want to bring up Hinata that much, but now that this question is brought up....
My view is this. She's not necessarily the better character as we know her, but she had more
potential than Sakura as a MC (assuming Kishi used it right). Sakura is just some girl who loves Sasuke, and somehow made it to team 7, and despite not being connected to anything not Sasuke related, she's constantly associated with Team 7. The best example is how Kishi had to stretch some things to make Sakura have a role in the Kaguya fight. Kishi built up this world where only Ootsutsuki family members have top-tier potential without killing themselves. Yet, in all this, we have this one normal girl with no special bloodline somehow supposed to keep up with this, but can't because the writer can't think of anything, so we get this constant whining that Sakura's infamous for. Sakura also has a weak motivation (compared to Naruto and Sasuke). Her biggest pain is that Sasuke left her. Meanwhile, you get Naruto who was never loved in his life, and Sasuke, who had everything he loved destroyed. With this, Sakura's life seems pretty minor.
Here's how Hinata differs. Regardless of what you think of her now, she has potential. Here's a girl with a special bloodline ability and is a member of the Ootsutsuki family (descendant). Bam! Right there Kishi could have introduced abilities for Hinata to keep up with the 2 MCs being a member of an ancient clan related to them. Hinata fits in better. It makes sense for a team of Ootsutsuki descendants to exist instead of 2 of them and one random girl. As for motivation, yes, Naruto was her main motivation, but there's more to her. Unlike Sakura, Hinata has a tragic backstory. She was a part of a high-society, but was kicked out because she was weak. That's powerful! Hinata would not get that old quickly if we saw her develop, and she was relevant. Naruto was never loved, Sasuke lost his love, Hinata was rejected by those she loved. Do you see a pattern? Hinata had the same character qualities as Naruto and Sasuke. Why Hinata was not put on as the female lead, I don't know.
There is also the fact that Sakura puts Sasuke above anyone else.
Well, this too to a certain extent.