[Discussion] The best friendship relationship in anime history

[Defence]

Ed and Al. Best friends and brothers

 

[Stacks]

Gon - Killua

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Naruto - Sasuke

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Alibaba - Aladdin

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Shinichi - Migi

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Hashirama - Madara

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[Hexuze]

Nej and Leo may take the cake, with just a single episode it showed an amazing friendship.

Spoiler

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[GhostProject]

I'm impressed OP, I was not expecting LeLouch and Suzaku in the opening post. Despite the politics of it, they have an extremely open and loyal friendship.

 

[RuckenTM]

I agree with his list.