Something about Itachi's DISEASEsS

Ovan

Anbu Operative 🎭
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Itachi overdid himself all his life. His body was bound to fall apart sooner or later. He was dancing up the ranks like it was playground games.

I think you are right about the susanoo. In the real world, being around something that is harmful to the body could give you cancer. Too much such, people can get cancer. Being around the susanoo may have gave him cancer.
 
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