Do you think Shisui had the first hokage's cells when using kotoamatsukami. I don't see how shisui could become famous for a jutsu one could only use every 10 years. Shisui was a young man I am guessing early 20's as he and itachi were friends. Itachi also knew that using the first hokage's cells shortened the process. Maybe because shisui was the first to use this method. Because if not shisui could have only used it once. Twice if you want to be optimistic and figure he developed MS at a young age.
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