Depends really
On?????

At times taking a life can be harder than saving life in the context of NV
IRL genrally saving life is more difficult
Is this about Tsunade.
I feel the same way actually, you can't really equate Pain's resurrection like jutsu to the difficulty Naruto & Sasuke had defeating Kaguya.
But Naruto and Sasuke does all that to save lives also not just people but animals, plants.
But in the way to saves all lives/living being, taking a lives involve/cant be avoided also in NV cases
Sasuke :- Takes lives. Tries of change the world
Vs
Sakura :- Tries to heal people, yet they die. You choose