Kakuzu with mid difficulty can kill Sasuke IMO.
If Sasuke uses Amaterasu Kakuzu would just use his earth release to strengthen his skin and let the four hearts out of his body, even if the earth heart dies from Amaterasu, there would be 4 hearts chasing after Sasuke and using combo attacks like fire+wind, I doubt Sasuke would survive.
Don't forget that it took Kakashi, Choji, Ino, Shikamaru (Planner, with his plan he tricked Hidan letting him kill one of Kakuzu's hearts), Naruto and Yamato (to counter the fire+wind combo), and finally Naruto to defeat Kakuzu, I don't think Sasuke alone would be able to defeat someone like him, also remember that Kakuzu's battle experience > Sasuke's.