Uchiha's don't have the body requirements nor chakra levels to use sage mode. Madara cheated by taking hashirama flesh and absorbing his sage chakra into it to achieve it. If they could they would be the body and eyes
Hmm jiraiya is from no known clan yet has sage mode
Minato is from no known clan yet has perfect sage mode
Kabuto has sage mode although he modified his body
One doesn't need to be a Uzumaki or senju to learn sage mode, just have enough chakra and skill.
Heck Naruto when even 3 tails couldn't defeat Orochimaru managed to learn Sage Mode at the time, it doesn't set the bar that high learning sage mode.
For sage mode it requires high chakra, strong body and talent.
Sasuke was able to defeat team 7 physically when Naruto went to orochimaru lair
Sasuke chakra surpassed jubi madara after VOTE2
Sasuke got talent in Curse seal noted by juugo when Sasuke did partial transformation
I am on my mobile sorry if my post doesn't look good.