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There's nothing that hints rest being capable of restoring a blind eye, hence the importance of EMS. Once you lose the ability it's gone. What's even worse about this argument is that Karin healed him after he fought the Kage, then partially healed him again after the Danzo fight.
Madara's circumstances are unexplained. When Sasuke lost the ability to use his Sharingan Susanoo disappeared as well, so you obviously do need the Sharingan active to use Susanoo.
I highly doubt that Sasuke and Madara were the only two in a span of several several decades to only get eyes from immediate family members.
He wasn't completely blind but fatigued from no rest of the eye, Karins healing doesn't mean his eyes for the most part, it's wounds an body fatigue that was being healed given his eyes a boost but not healing. It was from Sasuke not resting his eyes.. If he'd had rest, he still would've been able to access it but not for long..
Itachi was using his for along time an could only hold it for bursts.. Which is why he handle his opponents quickly..
It took zetsu along time to figure out the EMS because the blood is diluted.. Sasuke & Madara are the only1's who awakend it otherwise zetsu wouldn't have got to them for the power he needed..
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Sasuke's last attack on Itachi with Kirin, Itachi didn't have MS activated for Susano'o which would prove Tobirama right of not really needing the eyes but the brain..
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Itachi was blind here technically but Susano'o is activated.. It's the brain not the eye itself..