Akatsuke pair itself, or Akatsuki members that have been paired up in the manga, cause i dont think anyone could take Itachi and Nagato as seen in the War arc.
Are you people kidding me? Okay, Orochimaru and Tsunade are indeed weaker than Jiraiya, who fought all of Pien/Pein's six paths and dispatched 3 alone in old age. Kisame and Itachi backed down from a fight between Jiraiya. So Itachi and Kisame are out of the question. Jiraiya could solo most of the pairs. With the help of Orochimaru/Tsunade, Pein/Pien and Konan would be a considerably challenging fight but would lose in the end. They aren't sannin for any reason. They earned it and a bunch of missing ninja arent going to defeat them because of a name! Sakura and Chiyo, fairly weak characters took out sasori. C'mon? You guys give Akatsuki too much Credit. Itachi is indeed a very skilled ninja and would dominate many opponents, but he could not take Jiraiya. Most of the Akatsuki were defeated by ninja who aren't too significantly powerful. I forgot something else i was going to say... Oh well. Anywho. "Tobi" and Pein are the only true threats. Maybe Itachi in good health. Oh, Kisame was defeated by Gai, who is a Jounin of the Hidden Leaf. Many ninja are more powerful than Gai.